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Systemic Anti-Cancer Therapy Regimen Library

Home > GYN OV Advanced - niraparib > GYN - niraparib 300 mg
This regimen is a component of GYN OV Advanced - niraparib

niraparib 300 mg (GYN OV Advanced - niraparib)

Treatment Overview

Recommended starting dose for body-weight 77 kg or greater and baseline platelet count 150 x 109/L or greater.

Cycle 1 (and all further cycles) - 28 days

Cycle length:
28

Cycle details

Cycle 1 (and all further cycles) - 28 days

Medication Dose Route Days Max Duration
niraparib 300 mg Once daily oral administration 1 to 28
domperidone 10 mg Three times daily oral administration 1

Full details

Cycle 1 (and all further cycles) - 28 days

Day: 1

Medication Dose Route Max duration Details
niraparib 300 mg Once daily oral administration
Instructions:
  • Swallow whole with a glass of water, do not crush, chew.
  • Take at approximately the same time each day, bedtime administration may help reduce nausea.
domperidone 10 mg Three times daily oral administration
Instructions:

When required for nausea and/or vomiting.

The choice of rescue antiemetic may be substituted to reflect institutional policy or individual patient characteristics.

Day: 2

Medication Dose Route Max duration Details
niraparib 300 mg Once daily oral administration
Instructions:
  • Swallow whole with a glass of water, do not crush, chew.
  • Take at approximately the same time each day, bedtime administration may help reduce nausea.

Day: 3

Medication Dose Route Max duration Details
niraparib 300 mg Once daily oral administration
Instructions:
  • Swallow whole with a glass of water, do not crush, chew.
  • Take at approximately the same time each day, bedtime administration may help reduce nausea.

Day: 4

Medication Dose Route Max duration Details
niraparib 300 mg Once daily oral administration
Instructions:
  • Swallow whole with a glass of water, do not crush, chew.
  • Take at approximately the same time each day, bedtime administration may help reduce nausea.

Day: 5

Medication Dose Route Max duration Details
niraparib 300 mg Once daily oral administration
Instructions:
  • Swallow whole with a glass of water, do not crush, chew.
  • Take at approximately the same time each day, bedtime administration may help reduce nausea.

Day: 6

Medication Dose Route Max duration Details
niraparib 300 mg Once daily oral administration
Instructions:
  • Swallow whole with a glass of water, do not crush, chew.
  • Take at approximately the same time each day, bedtime administration may help reduce nausea.

Day: 7

Medication Dose Route Max duration Details
niraparib 300 mg Once daily oral administration
Instructions:
  • Swallow whole with a glass of water, do not crush, chew.
  • Take at approximately the same time each day, bedtime administration may help reduce nausea.

Day: 8

Medication Dose Route Max duration Details
niraparib 300 mg Once daily oral administration
Instructions:
  • Swallow whole with a glass of water, do not crush, chew.
  • Take at approximately the same time each day, bedtime administration may help reduce nausea.

Day: 9

Medication Dose Route Max duration Details
niraparib 300 mg Once daily oral administration
Instructions:
  • Swallow whole with a glass of water, do not crush, chew.
  • Take at approximately the same time each day, bedtime administration may help reduce nausea.

Day: 10

Medication Dose Route Max duration Details
niraparib 300 mg Once daily oral administration
Instructions:
  • Swallow whole with a glass of water, do not crush, chew.
  • Take at approximately the same time each day, bedtime administration may help reduce nausea.

Day: 11

Medication Dose Route Max duration Details
niraparib 300 mg Once daily oral administration
Instructions:
  • Swallow whole with a glass of water, do not crush, chew.
  • Take at approximately the same time each day, bedtime administration may help reduce nausea.

Day: 12

Medication Dose Route Max duration Details
niraparib 300 mg Once daily oral administration
Instructions:
  • Swallow whole with a glass of water, do not crush, chew.
  • Take at approximately the same time each day, bedtime administration may help reduce nausea.

Day: 13

Medication Dose Route Max duration Details
niraparib 300 mg Once daily oral administration
Instructions:
  • Swallow whole with a glass of water, do not crush, chew.
  • Take at approximately the same time each day, bedtime administration may help reduce nausea.

Day: 14

Medication Dose Route Max duration Details
niraparib 300 mg Once daily oral administration
Instructions:
  • Swallow whole with a glass of water, do not crush, chew.
  • Take at approximately the same time each day, bedtime administration may help reduce nausea.

Day: 15

Medication Dose Route Max duration Details
niraparib 300 mg Once daily oral administration
Instructions:
  • Swallow whole with a glass of water, do not crush, chew.
  • Take at approximately the same time each day, bedtime administration may help reduce nausea.

Day: 16

Medication Dose Route Max duration Details
niraparib 300 mg Once daily oral administration
Instructions:
  • Swallow whole with a glass of water, do not crush, chew.
  • Take at approximately the same time each day, bedtime administration may help reduce nausea.

Day: 17

Medication Dose Route Max duration Details
niraparib 300 mg Once daily oral administration
Instructions:
  • Swallow whole with a glass of water, do not crush, chew.
  • Take at approximately the same time each day, bedtime administration may help reduce nausea.

Day: 18

Medication Dose Route Max duration Details
niraparib 300 mg Once daily oral administration
Instructions:
  • Swallow whole with a glass of water, do not crush, chew.
  • Take at approximately the same time each day, bedtime administration may help reduce nausea.

Day: 19

Medication Dose Route Max duration Details
niraparib 300 mg Once daily oral administration
Instructions:
  • Swallow whole with a glass of water, do not crush, chew.
  • Take at approximately the same time each day, bedtime administration may help reduce nausea.

Day: 20

Medication Dose Route Max duration Details
niraparib 300 mg Once daily oral administration
Instructions:
  • Swallow whole with a glass of water, do not crush, chew.
  • Take at approximately the same time each day, bedtime administration may help reduce nausea.

Day: 21

Medication Dose Route Max duration Details
niraparib 300 mg Once daily oral administration
Instructions:
  • Swallow whole with a glass of water, do not crush, chew.
  • Take at approximately the same time each day, bedtime administration may help reduce nausea.

Day: 22

Medication Dose Route Max duration Details
niraparib 300 mg Once daily oral administration
Instructions:
  • Swallow whole with a glass of water, do not crush, chew.
  • Take at approximately the same time each day, bedtime administration may help reduce nausea.

Day: 23

Medication Dose Route Max duration Details
niraparib 300 mg Once daily oral administration
Instructions:
  • Swallow whole with a glass of water, do not crush, chew.
  • Take at approximately the same time each day, bedtime administration may help reduce nausea.

Day: 24

Medication Dose Route Max duration Details
niraparib 300 mg Once daily oral administration
Instructions:
  • Swallow whole with a glass of water, do not crush, chew.
  • Take at approximately the same time each day, bedtime administration may help reduce nausea.

Day: 25

Medication Dose Route Max duration Details
niraparib 300 mg Once daily oral administration
Instructions:
  • Swallow whole with a glass of water, do not crush, chew.
  • Take at approximately the same time each day, bedtime administration may help reduce nausea.

Day: 26

Medication Dose Route Max duration Details
niraparib 300 mg Once daily oral administration
Instructions:
  • Swallow whole with a glass of water, do not crush, chew.
  • Take at approximately the same time each day, bedtime administration may help reduce nausea.

Day: 27

Medication Dose Route Max duration Details
niraparib 300 mg Once daily oral administration
Instructions:
  • Swallow whole with a glass of water, do not crush, chew.
  • Take at approximately the same time each day, bedtime administration may help reduce nausea.

Day: 28

Medication Dose Route Max duration Details
niraparib 300 mg Once daily oral administration
Instructions:
  • Swallow whole with a glass of water, do not crush, chew.
  • Take at approximately the same time each day, bedtime administration may help reduce nausea.

Supportive Care Factors

Factor Value
Emetogenicity: Medium to high

Emetogenicity: MEDIUM to HIGH. Routine antiemetic premedication may not be required for continuous dosing of oral anti-cancer medicines with MEDIUM to HIGH emetic risk; an individualised approach is appropriate.

References

GlaxoSmithKline NZ Limited. Zejula Capsules New Zealand Data Sheet 11 September 2023. https://www.medsafe.govt.nz/profs/Datasheet/z/zejulacap.pdf (Accessed 19 March 2024)

* The medicines, doses, combinations, and schedule in this treatment regimen have been carefully reviewed against international best practice guidelines by specialists in medical oncology around New Zealand and this advice has been accepted for publication by Te Aho o Te Kahu (the Cancer Control Agency). Sometimes medicines that are used in routine clinical practice have not been through a formal review process by the NZ Medicines Regulator Medsafe and are therefore considered unapproved or off-label. These medicines are legally able to be prescribed through sections 25 and 29 of the Medicines Act and by obtaining informed consent from patients. All treatment regimens listed on this website have been through robust peer review and are considered an accepted standard of care, whether prescribed through sections 25 or 29 or carrying formal Medsafe Approval.

s29: This symbol indicates that some formulations of the associated medicine are legally only able to be prescribed under section 29 of the Medicines Act. You can see which formulations are section 29 by hovering over the s29 symbol. You can access full medication details from the New Zealand Formulary by clicking on the medication name. Each clinician retains full responsibility for ensuring they have complied with all relevant obligations and requirements of section 29 including obtaining informed patient consent prior to prescribing the applicable medicine.